Department of Molecular Reproduction, Development and
Indian Institute of Science
Bangalore 560 012
Duration of Grant:
The importance of cyclic nucleotide signaling in the biology and pathogenesis of M. tuberculosis
Abstract of Project :
Most of the proteins involved in cyclic AMP metabolism in mycobacteria were described for the first time in the Visweswariah laboratory, and their characterization has revealed their unique properties. The research in the U.S. will examine the roles of the enzymes in the biology of mycobacteria by creating gene knock outs of these proteins in Mycobacterium tuberculosis, and stud the properties of these mutant bacteria in the mouse model of infection as well as in macrophages. Should the bacteria be compromised in their pathogenic potential, some of the proteins could be the targets of novel therapeutics for treatment of tuberculosis.