Mr. Chhuttan Lal Meena

Grant Category: Fulbright-Nehru Doctoral and Professional Research Fellow
Field of Specialization: Medicinal Chemistry
Name: Mr. Chhuttan Lal Meena
Official Address and Designation:  Research Scholar
National Institute of Pharmaceutical
Education and Research (NIPER) 
Department of Medicinal Chemistry
Block-B, B-210, S.A.S. Nagar, Phase-10
Mohali, Punjab 160 062  
Telephone (O): 91-172-2292024
Duration of Grant: Nine Months                        
Project Title: Synthesis of New Thyrotropin- Releasing Hormone (TRH) analogues
Abstract of Project :
Thyrotropin-Releasing Hormone (TRH) is a key hormone responsible for proper brain-body coordination. It has been investigated for the possible applications in the treatment of epilepsy, Parkinson's disease and other Central Nervous System (CNS) disorders. TRH acts on two sub-types of receptors: TRH-R1 and TRH-R2. The activation of TRH-R1 receptor leads to analogues with endocrine effects of TRH; while activation of TRH-R2 receptor leads to analogues displaying selective CNS effects such as epilepsy and Parkinson's disease. The objective of my research during my Fulbright grant is to develop TRH analogues with selective TRH-R2 receptors. I have synthesized several TRH analogs with good CNS activity. I hope my research will ultimately would lead to the discovery of small neuroprotective peptides useful in the treatment of diseases like epilepsy, Parkinson's, Alzheimer's and several other motor neuronal disorders.

Academic Background :
Ph.D. Medicinal Chemistry NIPER-S, Mohali 2007-Till date
M. Pharm. Medicinal Chemistry NIPER-S, Mohali 2006
B. Pharm. Pharmaceutical Sciences Mohan Lal Sukhadia University, Udaipur 2002
Professional Background:
Senior Research Fellow NIPER-S, Mohali 2008-Till date
Junior Research Fellow NIPER-S, Mohali 2006 – 2008
Research Associate Jubilant Chemys Ltd., Noida 2006 – 2006
Chhuttan Lal Meena