Immunology Lab, Department of Zoology
University of Calcutta 35, Balygunge Circular Road Kolkata 700 019
91-33-24615445 Ext 286
Duration of Grant:
Mitochondrial dysfunction autophagy cross talk in cancer
Abstract of Project :
Mitochondrial dysfuntion is a major factor in cancer cell death. However, it has been difficult to understand whether the degeneration of the mitochondria in these cells as well as in immune cells is a cause or effect of the cell death. One of the difficulties in the study of mitochondria in cancer has been our limited understanding of how damaged mitochondrial proteins and lipids are degraded in steady state. There are currently at least three distinct mechanisms known for mitochondrial protein turnover. Among them autophagic degradation and proteasome-dependent pathways are important. With the exception of the mitochondrial proteases, which have been studied for some time, the molecular mechanisms and regulation of mitochondrial turnover via autophagy is less well characterized. The project aims to investigate these molecular and cellular mechanisms that underlie these phenomena using breast cancer cell line models and other cancers.